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ebv nasopharyngeal carcinoma prognosis

Testing of the tumor for EBV is also recommended. Multiple risk factors, including host genetics, environmental factor, and EBV infection, have been linked to the development of NPC, particularly in the familial clustering cases. 1,2 More than 70% of new NPC cases were reported in East and Southeast Asia. Presented in partnership with Desjardins. Epstein-Barr virus (EBV) is a member of the herpesvirus family that can infect humans. Epstein–Barr virus DNA; Meta-analysis; Nasopharyngeal carcinoma; Prognosis. To better understand the genetic landscape, an integrated … Nasopharyngeal cancer is a rare type of head and neck cancer.It starts in the upper part of your throat, behind the nose. NIH We investigated the prognosis of NPC patients with residual cervical lymphadenopathy and assessed the diagnostic and prognostic values of Epstein-Barr virus (EBV) DNA in these patients. A prognostic factor is an aspect of the cancer or a characteristic of the person (such as whether they smoke) that the doctor will consider when making a prognosis. Nasopharyngeal carcinoma is an Epstein-Barr Virus (EBV) associated malignancy which is highly prevalent in Southeast Asia. Nasopharyngeal carcinoma (NPC), the most common head and neck cancer, is characterized by distinct geographic distribution and familial aggregation. If we are not able to reach you by phone, we will leave a voicemail message. We will reply by email or phone if you leave us your details. Imaging tests may include: 1. Up till now there is limited prognostic data on the role of TILs in NPC, so we assessed the prognostic role of TILs in Epstein-Barr-virus (EBV) positive and worse prognosis in solid tumors. Very rarely does Epstein-Barr virus lead to cancer, which suggest… Nasopharyngeal carcinoma (NPC) is a cancer rising from nasopharynx epithelium [].Unlike other head and neck cancers, NPC has remarkably skewed ethnic and geographic distributions [].In certain regions such as southeast Asia and northern Africa, NPC has relatively higher prevalence than elsewhere, with viral infection, genomic landscape and some environment factors … This allows the head and neck surgeon to visualize the tumor and its extent. Since NPC is located in a silent and painless area, diagnosis typically occurs at the advanced stages. Unfortunately most nasopharyngeal cancers are found at a later stage, when the cancer has spread to lymph nodes or distant organs. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. EBV infection is tightly associated with the development of NPC, but EBV encoded miRNAs in cancer invasion and metastasis remains largely unknown. Treatment of stage II nasopharyngeal cancer may include the following: Chemotherapy given with radiation therapy, followed by more chemotherapy. Genetic studies indicate that mutations in chromatin-modifying enzymes are the most frequent genetic alterations in NPC. Here, we reported that, in the univariate analysis, SOX2 expression was correlated with a poorer distant metastasis-free survival (DMFS). EBV-related antibodies have been widely used as screening markers for early nasopharyngeal carcinoma (NPC) detection. Radiat Oncol (Lond, Engl) 10:89 Endemic to China, the malignancy shows a variable rate of occurrence ranging from high incidence in the Southern part of China to a low rate in the White population and Northern China with the incidence ranging from 15 to 50 per 100000. Methods: The ISH for EBV-encoded early RNA (EBER) is the most effective … The pathogenic role of Epstein-Barr virus (EBV) for the initiation and progression of nasopharyngeal carcinoma (NPC) has been highly investigated since EBV-DNA was identified in an NPC tumor specimen . Late presentation is a common issue and early detection could be the key to reduce the disease burden. Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer that is endemic to the southern region of China. Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor ubiquitously associated with the Epstein‐Barr virus (EBV), which is highly prevalent in South China, Southeast Asia, and North Africa. 2019 Mar;132:223-229. doi: 10.1016/j.radonc.2018.10.010. These other health issues are called comorbidities. © 2021 Canadian Cancer Society All rights reserved. Zhang W, Chen Y, Chen L, Guo R, Zhou G, Tang L, Mao Y, Li W, Liu X, Du X, Sun Y, Ma J. link. The closest association with EBV infection is seen in undifferentiated nasopharyngeal carcinoma (NPC), which is endemic in the southern Chinese population. Preliminary investigations suggest that the presence of Epstein‐Barr virus (EBV) genomes in neck metastases from an occult primary may be diagnostic and predictive of NPC. Prognosis and survival depend on many factors. Cancer 98(1):74–80 Radiotherapy is the primary treatment modality, and concurrent chemoradiotherapy with or without adjuvant chemotherapy is the primary regimen for … Non-keratinizing undifferentiated carcinoma (the most common type in the U.S.) Diagnosis. Nasopharyngeal cancer that has spread to the lymph nodes in the neck (cervical lymph nodes) has a poorer prognosis. Only a doctor familiar with your medical history, the type and stage and other features of the cancer, the treatments chosen and the response to treatment can put all of this information together with survival statistics to arrive at a prognosis. Lancet (Lond, Engl). Neck swelling, nasal obstruction, and epistaxis are the most common presenting symptoms. Background: Nasopharyngeal carcinoma (NPC) is an entity belonging to up-per aerodigestive tract Cancers. : a systematic review and meta-analysis of 7836 cases. Medicine (Baltimore). It is endemic to southern China and Asia and is etiologically associated with the Epstein–Barr virus (EBV) Ma, Hui, & Chan, 2017). Nasopharyngeal carcinoma (NPC) is an uncommon cancer of the back of the head and throat, which has a distinctive ethnic and geographic distribution. Almost all cases of type 2 and type 3 are related to EBV and occur in the area where EBV is endemic. This site needs JavaScript to work properly. However, due to its low positive predictive rate, it is ess … If nasopharyngeal cancer has spread to the lymph nodes in the lower areas of the neck, the prognosis is also poorer. Nasopharyngeal carcinoma (NPC) is originated from the epithelial cells of nasopharynx, Epstein-Barr virus (EBV)-associated and has the highest incidence and mortality rates in Southeast Asia. For example, if the 5-year relative survival rate for a specific stage of nasopharyngeal cancer is Radiation therapy to the tumor and lymph nodes in the neck. Cancer Lett 374(1):22–30 doi: 10.1097/MD.0000000000000845. Genetic hallmarks of NPC are not completely known but include deletion of the p16 (CDKN2A) locus and mutations in NF-κB pathway components, with a relatively low total mutational load. Or write us. As therapeutic modalities for nasopharyngeal carcinoma (NPC) are limited, immunotherapy could be a potential alternative. Shi Z, Jiang W, Chen X, Xu M, Wang X, Zha D. Ther Adv Med Oncol. COVID-19 is an emerging, rapidly evolving situation. Keywords: Nasopharyngeal carcinoma, Circulating tumor cells, Epstein-Barr virus DNA, Prognosis, Cut-off point Introduction Circulating tumor cells (CTCs) count using the CellSearch system (Janssen Diagnostics, … Purpose: To investigate the prognostic effect of the concentrations and clearance rates of plasma EBV DNA in metastatic/recurrent nasopharyngeal carcinoma (NPC). Epstein-Barr virus (EBV) is associated with multiple types of human cancer, including lymphoid and epithelial cancers. However, the prognostic value of subsequent EBV DNA levels (mid or post treatment) for NPC is needed to identify by a large cohort of patients. X-ray Once your doctor has determi… 95% of all people in the U.S. are exposed to this virus by the time they are 30–40 years old. We performed a meta-analysis of studies including data from 8128 patients to evaluate the prognostic value of EBV DNA in NPC patients. Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in certain areas of Southern China, Southeastern Asia and Northern Africa. ORPHA:150 Classification level: Disorder. Introduction Nasopharyngeal carcinoma (NPC) is a malignant cancer, which is located behind the nose at the very upper part of the throat. 1 There were approximately 42,100 new cases of NPC in China in 2013, accounting for 1.14% of all new cancer cases in China. Nasopharyngeal Carcinoma … A2018425/Guangdong Medical Research Foundation, FS0AA-KJ218-1301-0006/the Science and Technology Innovation Project from Foshan, Guangdong, Tang LL, Chen WQ, Xue WQ, He YQ, Zheng RS, Zeng YX et al (2016) Global trends in incidence and mortality of nasopharyngeal carcinoma. Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated tumor occurring in southeastern Asia. The clinical utility of plasma Epstein-Barr virus DNA assays in nasopharyngeal carcinoma: the dawn of a new era? If cancer cells are not found in the margin, it is called a negative margin. USA.gov. Liu SL, Sun XS, Li XY, Tang LQ, Chen QY, Lin HX, Liang YJ, Yan JJ, Lin C, Guo SS, Liu LT, Li Y, Xie HJ, Tang QN, Liang H, Guo L, Mai HQ. People who are under 60 tend to have a better prognosis than people who are over 60. Experimental Design: Thirty relapsed and four previously nontreated metastatic NPC patients were treated according to the consensus guidelines of the head and neck cancer team in our hospital (i.v. Keywords: nasopharyngeal carcinoma; EBV; oncogenesis; infection; signaling pathway 1. Most people with nasopharyngeal carcinoma have regional metastases. As its symptoms are usually silent and painless, the patients mostly are diagnosed in the advanced stages of the disease, leading to poor prognosis [1]. Its prognosis remains bleak because of the late stage at diagnostic. Type 2 is differentiated non-keratinizing carcinoma, and type 3 is undifferentiated nonkeratinizing carcinoma and is the most common form of nasopharyngeal cancer. The EBV DNA levels have a significant prognostic impact in patients with NPC. What Is The Prognosis For Nasopharyngeal Cancer? Plasma levels of Epstein-Barr virus (EBV) DNA have been employed to predict survival outcomes of patients with nasopharyngeal carcinoma (NPC). In our country, it is the leading cause of head and neck cancers. Due to insidious onset, it is difficult to diagnose NPC from clinical symptoms. The following are prognostic and predictive factors for nasopharyngeal cancer. Nasopharyngeal carcinoma (NPC) differs from malignant tumors arising from other head and neck mucosal sites in epidemiology, pathological types, and treatment [].NPC has a distinct ethnic and geographical distribution in Guangdong, South China, where environmental factors, genetic predisposition, and Epstein-Barr virus (EBV) infection play important roles in its pathogenesis. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Discover how 16 factors affect your cancer risk and how you can take action with our interactive tool – It’s My Life! In our country, it is the leading cause of head and neck cancers. Non-keratinizing squamous cell carcinoma has a better prognosis than other types of nasopharyngeal cancer. Background: Plasma levels of Epstein-Barr virus (EBV) DNA have been employed to predict survival outcomes of patients with nasopharyngeal carcinoma (NPC). In view of the factors that affecting the prognosis of NPC also include age and gender (Xiao et al. The goal of this study was to test this proposition. A relative survival rate compares people with the same type and stage of cancer to people in the overall population. If there are cancer cells in the margin, it is called a positive surgical margin. Conclusion: 387(10022):1012–1024 Here, we used H3K27ac chromatin immune precipitation … Positron emission tomography (PET) 4. Prognostic and predictive factors are often discussed together. (Screening is testing for cancer in people without any symptoms.) 1 INTRODUCTION. EBV-miR-BART8-3p is a useful biomarker predicting distant metastasis and poor survival of NPC. To compare the NPC-related diagnostic value of EBV RecombLine test (Mikrogen, Germany) with a standardized immunoblot assay [Fachiroh J, Schouten T, Hariwiyanto B, Paramita DK, Harijadi A, Haryana SM, et al. Hazard ratios (HRs) and confidence intervals (CIs) were extracted from the studies or calculated and pooled to assess the association between EBV DNA levels pre-treatment (pre-DNA), mid-treatment (mid-DNA), and post-treatment (post-DNA) on clinical outcomes. Subgroup analysis showed that the HR of post-DNA wasn't influenced by different detection time of post-DNA (P = 0.22, I2 = 33.2%). Nasopharyngeal cancer is a type of head and neck cancer that occurs when cells in the nasopharynx, the upper part of the throat behind the nose and near the base of the skull, grow out of control.. Knowing the structures and how the nasopharynx work will help an individual understand nasopharyngeal carcinoma. Experimental Design: Thirty relapsed and four previously nontreated metastatic NPC patients were treated according to the consensus guidelines of the head and neck cancer team in our hospital (i.v. Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated cancer characterized by a poor prognosis and a high level of lymphocyte infiltrate. Its prognosis remains bleak because of the late stage at diagnostic. NPC is caused by a combination of factors: viral, environmental influences, and heredity. -, Chua DTT, Sham JST, Kwong DLW, Au GKH (2003) Treatment outcome after radiotherapy alone for patients with Stage I–II nasopharyngeal carcinoma. A total of 22 studies with 8128 patients was included for analysis. The combined detection of CTCs and EBV-DNA could better predict the prognosis of NPC compared with the single detection of EBV-DNA. Results: Prognostic value of gross tumor regression and plasma Epstein Barr Virus DNA levels at the end of intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma. 1 World Health Organization type III is the most common pathologic type of NPC in high‐prevalence areas and is believed to be associated with Epstein‐Barr virus (EBV) infection. The Epstein-Barr virus is one of the most common viruses. However, the prognostic value of subsequent EBV DNA levels (mid or post treatment) for NPC is needed to … Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is the most common cancer originating in the nasopharynx, most commonly in the postero-lateral nasopharynx or pharyngeal recess (fossa of Rosenmüller), accounting for 50% of cases.NPC occurs in children and adults. Clinical presentation, diagnosis, treatment, and prognosis ... Clearly, the anti-EBV serologic findings separate the WHO type 1 tumors from the WHO type 2 and 3 tumors. Background. Nasopharyngeal carcinoma (NPC) is a heterogeneous epithelial tumour highly prevalent in East and Southeast Asia [].It is characterised by Epstein–Barr virus (EBV) infection and heavy lymphocyte infiltration [].These special features of the NPC tumour microenvironment (TME) indicate the potential benefits of immune checkpoint inhibitors (ICIs).  |  Nasopharyngeal carcinoma is the most common malignant tumor of the head and neck in Southeast Asia and originates from the epithelium of the nasopharynx. Computerized tomography (CT) 2. The patient with nasopharyngeal carcinoma (NPC) frequently is initially seen with regional node dissemination. Nasopharyngeal carcinoma (NPC) is an uncommon cancer of the back of the head and throat, which has a distinctive ethnic and geographic distribution. Epidemiology studies link NPC to genetic predisposition, Epstein-Barr virus (EBV) infection, and environmental factors. The diagnostic and prognostic values of plasma Epstein-Barr virus DNA for residual cervical lymphadenopathy in nasopharyngeal carcinoma patients: a retrospective study. They both play a part in deciding on a treatment plan and a prognosis. Males are more commonly affected, with a male to female ratio of 3:1. 2015 May;94(20):e845. Huang D, Liu Q, Zhang W, Huang C, Zheng R, Xie G, Wang H, Jia B, Shi J, Yuan Y, Deng M. Cancer Cell Int. Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong Province, People's Republic of China. Nasopharyngeal (nay-zoh-fuh-RIN-jee-ul) carcinoma is cancer that occurs in the nasopharynx, which is located behind your nose and above the back of your throat.Nasopharyngeal carcinoma is rare in the United States. -, Chan AT, Lo YB, Chan LY, Ma BB, Leung SF, Mo F et al (2002) Plasma Epstein–Barr virus DNA and residual disease after radiotherapy for undifferentiated nasopharyngeal carcinoma. Epstein-Barr virus DNA level as a novel prognostic factor in nasopharyngeal carcinoma: A meta-analysis. Magnetic resonance imaging (MRI) 3. The higher the stage, the larger the tumour. Nasopharyngeal cancer 5-year survival rates: Localized (no sign the cancer has spread outside the nasopharynx): 82% A high level of Epstein-Barr virus (EBV) antibodies in the blood after treatment indicates a poorer prognosis. Tumours with negative surgical margins have a better prognosis. 1, 2 In a 2018 global report, morbidity due to nasopharyngeal carcinoma (NPC) accounted for approximately 0.7% of 36 cancers worldwide, with a total of 129 079 cases, and mortality due to NPC accounted for … That means cancer cells from the initial tumor have migrated to nearby areas, such as lymph nodes in the neck. Nasopharyngeal carcinoma (NPC) has distinct characteristics from other head and neck cancers and accounts for only 0.7% of all cancer cases diagnosed in 2018 globally. Nasopharyngeal carcinoma (NPC) is endemic in Southern China and Southeast Asia, where a peak incidence of 50 cases per 100 000 has been reported (Wee et al, 2010).  |  EBV infection is closely related to the development and progression of nasopharyngeal carcinoma, but it is still to be clarified how EBV infection promotes tumorigenesis. chemotherapy first, … Smaller tumours (less than 2 cm) have a better prognosis than larger tumours. The size of the tumour is usually related to the stage of nasopharyngeal cancer. This makes it likely that the nasopharyngeal cancer has also spread to distant organs. Nasopharyngeal carcinoma (NPC) most frequently occurs in southern China and southeast Asia. Spread to lymph nodes Nasopharyngeal cancer that has spread to the lymph nodes in the neck (cervical lymph nodes) has a poorer prognosis. 1 INTRODUCTION. This makes it likely that the nasopharyngeal cancer has also spread to distant organs. -. ... 86 700 new cases of NPC and 50 800 deaths in 2012. The World Health Organization does not have set preventative measures for this virus because it is so easily spread and is worldwide. Objectives. Nasopharyngeal carcinoma (NPC) arises from the lining of the nasopharynx, the narrow tubular passage behind the nasal cavity. Once the diagnosis is confirmed, your doctor orders other tests to determine the extent (stage) of the cancer, such as imaging tests. Nasopharyngeal carcinoma (NPC) arises from the epithelium of the nasopharynx and is a rare tumor in most parts of the world, including the United States. New evidence indicates that exosomes may play as an important mediator in this EBV-tumorigenic progress. Currently, the diagnosis and treatment of nasopharyngeal carcinoma (NPC) patients with residual cervical lymphadenopathy following radical radiotherapy with or without chemotherapy are challenging. The age of the patient The health status of the patient Family history Consumption of salted fish in the diet Tobacco smoking The size of the tumor (2) The type of nasopharyngeal cancer (1) The stage of cancer whether it … Purpose: To investigate the prognostic effect of the concentrations and clearance rates of plasma EBV DNA in metastatic/recurrent nasopharyngeal carcinoma (NPC). 2014 ). Prognostic and clinicopathological value of Ki-67 expression in patients with nasopharyngeal carcinoma: a meta-analysis. 2020 Oct 12;20:498. doi: 10.1186/s12935-020-01587-z. EBV infection may promote NPC progression by disrupting the expression of miR-3182. 2017 Dec 29;36(1):98. doi: 10.1186/s40880-017-0264-x. Concurrent chemo-radiotherapy is one of the main treatments for NPC. Background: Nasopharyngeal carcinoma (NPC) is an entity belonging to up-per aerodigestive tract Cancers. This area is called the nasopharynx. 2019 Mar 29;39(1):14. doi: 10.1186/s40880-019-0357-9. Nasopharyngeal carcinoma frequently spreads (metastasizes) beyond the nasopharynx. Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer with high prevalence rates in southern China, Southeast Asia, North Africa, the Middle East and Alaska.1 Currently, tumor, node and metastasis (TNM) staging is the main tool in determining treatment strategy and assessment of prognosis. That's probably because the nasopharynx isn't eas… Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. 2020 Sep 20;12:1758835920951346. doi: 10.1177/1758835920951346. 1. eCollection 2020. Serum amyloid A (SAA) has been associated with the development and prognosis of cancer. HHS Clipboard, Search History, and several other advanced features are temporarily unavailable. Nasopharyngeal carcinoma (NPC) is originated from the epithelial cells of nasopharynx, Epstein–Barr virus (EBV)‐associated and has the highest incidence and mortality rates mostly in Southeast Asia. Background. 2016 Oct;95(40):e5130. The latter 2 types are also most responsive to treatment. Bookmarks (0) Head and Neck. The lower the stage, the better the prognosis. The plasma concentration of Epstein-Barr virus (EBV) DNA is associated with tumor burden and prognosis in patients with nasopharyngeal carcinoma (NPC), but data on the relationship between viral load and 18F-FDG PET functional parameters are lacking. Heat shock protein 90α (HSP90α) is an important member of the heat shock protein … NPC is more widespread in Southern China and South East Asia. Mid-DNA levels predicted overall survival and progression-free survival with an HR (95% CI) of 3.02 (1.54, 5.29) and 3.15 (2.05, 4.83). NPC differs significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. People who have other health problems, such as heart or lung disease, have a poorer prognosis. Thus, there is an urgent need for non-invasive, high-performance biomarkers to aid the clinical diagnosis of NPC. Yao JJ, Zhou GQ, Wang YQ, Wang SY, Zhang WJ, Jin YN, Zhang F, Li L, Liu LZ, Cheng ZB, Ma J, Qi ZY, Sun Y. Chin J Cancer. eCollection 2020. Nasopharyngeal carcinoma (NPC) ... they reported that SAA wasn't an independent prognostic factors and they did not assess the use of integrated SAA and EBV DNA (S‐D grade) in the prognosis of NPC. Cancer Commun (Lond). In the United States and other countries where nasopharyngeal cancer (NPC) is fairly rare, doctors do not recommend routine screening for this cancer. NLM Nasopharyngeal carcinoma accounts for ~70% of all primary malignancies of the nasopharynx, and although rare in western populations, it is one of the most common malignancies encountered in Asia, especially China 1,3-5.It is commonly diagnosed between 40 and 60 years. If you have nasopharyngeal cancer, you may have questions about your prognosis. The presence of monoclonal EBV episomes in NPC tumor cells indicates that virus infection precedes the clonal expansion of the malignant cell population. Keywords: The significance of SOX2 in nasopharyngeal carcinoma (NPC), a tumor associated with Epstein-Barr virus (EBV), remains unclear. Please enable it to take advantage of the complete set of features! Nasopharyngeal carcinoma which is also known as nasopharyngeal cancer is a type of cancer on the neck and head that rarely occurs, but it could affect both males and females. A strong association betw … Liang SB, Zhang N, Chen DM, Yang XL, Chen BH, Zhao H, Lu RL, Chen Y, Fu LW. Sensitivity of plasma EBV DNA, an established NPC biomarker, for Stage I NPC is controversial. If nasopharyngeal cancer has spread to the lymph nodes in the lower areas of the neck, the prognosis is also poorer. Registered charity: 118829803 RR 0001, International Cancer Information Service Group. Currently, evaluation of NPC prognosis is mainly based on the tumor-node-metastasis (TNM) staging system. EBV infections are very common — you’ve probably already contracted the virus without even knowing it.  |  The effect of post-treatment EBV DNA level dominated that of pre-DNA and mid-DNA levels. Naso- and Oropharyngeal Carcinoma. 3 The primary … Pre-DNA levels predicted overall survival, progression-free survival, distant metastasis-free survival, and local-regional failure survival with HRs (95% CIs) of 2.70 (2.06, 3.54), 2.70 (2.12, 3.44), 3.49 (2.35, 5.17), and 2.00 (1.45, 2.76), respectively, and the corresponding HRs for post-DNA levels were 4.86 (3.30, 7.17), 6.29 (3.41, 11.60), 5.68 (2.71,11.93), respectively. INTRODUCTION. EBV detection of nonkeratinizing nasopharyngeal carcinoma is linked to EBV in 100% of cases, regardless of the ethnicity of the patients. Nasopharyngeal carcinoma is diagnosed by biopsy of the tumor, which is often performed in clinic with a use of a small endoscope. J Natl Cancer Inst 94(21):1614–1619 Late presentation is a common issue and early detection could be the key to reduce the disease burden. doi: 10.1097/MD.0000000000005130. Scientists are still researching how EBV leads to nasopharyngeal cancer, but it may be related to genetic material (DNA) from the virus affecting the DNA in the cells of the nasopharynx. The stage is the most important prognostic factor for nasopharyngeal cancer. We searched PubMed, Web of Science, and the Cochrane library for prospective and retrospective studies. Treatment of stage I nasopharyngeal cancer is usually radiation therapy to the tumor and lymph nodes in the neck. Molecular diversity of Epstein–Barr virus IgG and IgA antibody responses in nasopharyngeal carcinoma: a comparison of Indonesian, Chinese, and European subjects. A predictive factor influences how a cancer will respond to a certain treatment. -, Chua MLK, Wee JTS, Hui EP, Chan ATC (2016) Nasopharyngeal carcinoma. Primary Sites, Perineural Tumor and Nodes. Epidemiology. Thus, it is particularly important to identify sensitive and specific biomarkers for early diagnosis and prognosis . Keywords: Nasopharyngeal carcinoma, Circulating tumor cells, Epstein-Barr virus DNA, Prognosis, Cut-off point Introduction Circulating tumor cells (CTCs) count using the CellSearch system (Janssen Diagnostics, Raritan, NJ, USA) has been proved to have good prognostic value for metastatic breast cancer (Bidard et al. Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Nasopharyngeal Carcinoma. NPC is more widespread in Southern China and South East Asia. Imaging techniques (MRI and/or CT scan) may also help determine the extent of the tumor. Would you like email updates of new search results? The margin is the area of healthy tissue around a tumour that is removed along with the tumour during surgery. Introduction. Most nasopharyngeal cancers are nasopharyngeal carcinoma.There are three types of nasopharyngeal cancer: . Epub 2018 Oct 23. Background: Nasopharyngeal carcinoma. Nasopharyngeal carcinoma is cancer that occurs in the nasopharynx, which is located behind your nose and above the back of your throat. In conclusion, miR-3182 and EBV-miR-BART8-3p are highly expressed in nasopharyngeal carcinoma and correlated with distant metastasis and poor prognosis. -, He Y, Zhou Q, Shen L, Zhao Y, Lei M, Wei R et al (2015) A retrospective study of the prognostic value of MRI-derived residual tumors at the end of intensity-modulated radiotherapy in 358 patients with locally-advanced nasopharyngeal carcinoma. It occurs much more frequently in other parts of the world — specifically Southeast Asia.Nasopharyngeal carcinoma is difficult to detect early. Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) and occurs frequently in the south of China and Southeast Asian countries. Nasopharyngeal carcinoma (NPC), previously known as lymphoepithelioma, is a malignancy arising from the epithelium of the nasopharynx. 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To reach you by phone, we reported that, in the univariate analysis, SOX2 expression was with..., STATdx provides comprehensive decision support you can rely on - nasopharyngeal carcinoma in. A meta-analysis a total of 22 studies with 8128 patients to evaluate prognostic! Not have set preventative measures for this virus because it is called a negative margin also spread to tumor. Is mainly based on the tumor-node-metastasis ( TNM ) staging system cases, regardless of the nasopharynx new indicates!

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